OZONIZED ORAL GEL AS AN ADJUVANT IN THE TREATMENT OF PERIODONTAL DISEASE: A PRELIMINARY REPORT

D. Lauritano^1†, E. Qorri^2†, D. Mucchi3 and F. Carinci¹

¹Dental School, Department of Translational Medicine, University of Ferrara, Ferrara, Italy;
²Dental School, Albanian University, Tirana, Albania;
³Lab SRL, Codigoro, Ferrara, Italy

^†These authors contributed equally

*Correspondence to:
Dorina Lauritano, DDS
Dental School,
Department of Translational Medicine,
University of Ferrara, Ferrara, Italy
e-mail: dorina.lauritano@unife.it

Received:  24 July 2023 Accepted: 01 September 2023

2038-4106(2023) Copyright © by BIOLIFE This publication and/or article is for individual use only and may not be further reproduced without written permission from the copyright holder. Unauthorized reproduction may result in financial and other penalties. Disclosure: all authors report no conflicts of interest relevant to this article.

ABSTRACT

Ozonized oils have been demonstrated to induce the reduction of many oral microorganisms. The aim of this study was to evaluate the efficacy of a new ozonized oil formulation for the treatment of periodontal disease. A total of 10 patients with a diagnosis of chronic periodontitis were randomly selected, and a split-mouth scheme was used. All patients underwent to support periodontal therapy at the baseline measurement. Microbial sampling and analysis were performed in each selected site before supporting periodontal therapy. The selected site corresponded to the deepest periodontal pocket of the oral cavity. Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Fusobacterium nucleatum, Campylobacter rectus, and Total Bacterial Loading were evaluated through the quantification of total bacterial genome copies by PCR. Then, support periodontal therapy was done using an ultrasonic scaler. After support periodontal therapy, each patient was given ozonized sunflower seed oil [Ozoral gel, Innovares SRL, Sant’Ilario d’Enza (RE), Italy]. The patients were instructed to apply the gel daily after evening oral hygiene at home. After 2 weeks, microbiological samples were collected again in each patient and analyzed. A statistically significant difference was detected between Total Bacterial Loading (p<0.014) and Tannerella Forsythia (p<0.012) pre and post-ozonized sunflower seed oil treatment. Ozoral has demonstrated antiseptic properties. Additional studies with larger sample sizes are needed to confirm this preliminary result.

KEYWORDS: ozonized oil, ozone therapy, periodontal disease, periodontal pathogens