MUCOUS MEMBRANE PEMPHIGOID AFFECTING THE ORAL MUCOSAE: A BRIEF REVIEW

S. Galleggiante and A. Ferrara

School of Dentistry, University of Bari “Aldo Moro”, Bari, Italy

Correspondence to:
Sara Galleggiante, DDS
School of Dentistry,
University of Bari “Aldo Moro”,
Bari, Italy
e-mail: sara.galleggiante@libero.it

Received: 03 March 2023 Accepted: 19  April  2023

2038-4106(2023) Copyright © by BIOLIFE This publication and/or article is for individual use only and may not be further reproduced without written permission from the copyright holder. Unauthorized reproduction may result in financial and other penalties Disclosure: all authors report no conflicts of interest relevant to this article.

ABSTRACT
A mucous membrane pemphigoid is a group of immune-mediated mucocutaneous diseases characterized by the formation of blisters whose rupture leaves an erosive area. It is classified as a rare disease with an unknown aetiology, although some agents may be considered causative. The pathogenesis consists of a subepithelial detachment caused by autoantibodies against basement membrane proteins. The diagnosis is made by integrating clinical appearance, histopathology, and direct immunofluorescence. Other diagnostic aids are indirect immunofluorescence and enzyme linked immunosorbent assay. The main treatment is systemic and/or topical corticosteroids; in non-responsive patients, there are innovative alternative treatments with immunosuppressants and rituximab.

KEYWORDS: Pemphigoid, oral, vesicle, disease, medicine, pathology