Eur J Musculoskel Dis 2021 Sep-Dec;10(3):141-145
LETTER TO THE EDITOR
GORHAM-STOUT SYNDROME
G. Carnevali1 and L. Mavriqi2
1University of Ferrara, Italy
2University of Albania University, Albania
Correspondence to:
Giulia Carnevali, MD, DDS,
University of Ferrara,
Ferrara, Italy
e-mail: giulia.carnevali84@gmail.com
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Received: 2 September 2021 Copyright: |
ISSN: 2038-4106 This publication and/or article is for individual use only and may not be further reproduced without written permission from the copyright holder. Unauthorized reproduction may result in financial and other penalties. Disclosure: All authors report no conflicts of interest relevant to this article. |
ABSTRACT
Gorham-Stout syndrome (GSS) is a relatively rare condition with no known cause. It is distinguished by the breakdown of osseous matrices and the growth of vascular structures, leading to bone loss and subsequent fractures. Even though there has been much research on the disease’s pathogenetic pathways, its aetiology is still unclear, and there are a few different views about what caused it. The disease can affect the patient’s head, lower and upper extremities, vertebrae, and pelvis to varying degrees. The syndrome can also affect numerous bones at the same time. Pain, impaired functioning, and inflammation of the affected region are the hallmarks of a patient’s clinical picture of GSS. However, asymptomatic cases have been described, as have cases in which the diagnosis was confirmed after pathologic fractures. In this concise review, we will discuss the hypotheses concerning the disease’s origin, the clinical manifestations, the diagnostic strategy, and the therapy choices available for this extremely uncommon condition.
KEYWORDS: lymphatic, osteolysis, bone, resorption, vanishing disease
