EFFECT OF A NEW XENOGRAFT MATERIAL IN MANDIBULAR POST-EXTRACTION SITES: A CASE SERIES

W. Stablum¹, A. Pellati², A. Palmieri³ and L. Scapoli³

¹Private Practice, 38051 Borgo Valsugana (TN), Italy;
²Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy;
³Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy;

Correspondence to:
Annalisa Palmieri, PhD
Department of Medical and Surgical Sciences,
University of Bologna,
40138 Bologna, Italy
e-mail: annalisa.palmieri@unibo.it

Received: 22 February 2023 Accepted: 28 March  2023

2038-4106(2023) Copyright © by BIOLIFE This publication and/or article is for individual use only and may not be further reproduced without written permission from the copyright holder. Unauthorized reproduction may result in financial and other penalties Disclosure: all authors report no conflicts of interest relevant to this article.

ABSTRACT
The alveolus bone is a tooth-dependent tissue. The extraction of the dental element determines the resorption of the alveolar crest, which trophism is linked to the presence of the periodontal ligament. Several materials have been used to improve alveolar bone healing and maintain alveolar ridge. The aim of the study is to evaluate the effects of a new matrix of bovine bone processed at low temperature in association with a membrane of the bovine pericardium in post-extraction sites using histological analysis comparing treated and untreated alveoli. Five patients with non-recoverable teeth were enrolled
in the present study for teeth extraction. In treated sites, the alveolus was packed with Decellularized and Antigen-free Bovine Bone (RE-BONE® Ubgen, Padova, Italy) and subsequently covered with a bovine-derived pericardium membrane (SHELTER® FAST Ubgen, Padova, Italy). Four alveoli of two patients were left to heal spontaneously as control sites. The tissue sampling was performed during the implant site preparation four months after extraction. Specimens were decalcified, and sections were stained with hematoxylin and eosin. Bone histomorphometry of regeneration tissues from treated sites showed an average increase of 2.9% in bone tissue. However, no statistically significant differences can be detected since standard deviations are very high. Generally, the alveolar preservation technique is a valuable method to guarantee alveolar volume stability. The material studied here showed a slight increase in bone production after 4 months from a tooth extraction in treated sites, which is an expression of a good healing process. However, since the limited number of cases analyzed, additional studies are needed to verify the bone gain in alveolar bone healing.

KEYWORDS: bone, graft, alveolus, mandible, lower jaw