Eur J Musculoskel Dis 2024 Sep-Dec;13(3):23-25
ARTICLE
ANTI-INFLAMMATORY DRUG-LOADED POLYMERIC NANO-HYBRIDS HAVE SIGNIFICANT POTENTIAL IN THE FIELD OF DENTISTRY
A. Coppola1*, R. Padula2, A. Annicchiarico3 and C. Annicchiarico3
1 Private practice, Studio Armando Coppola, Corso Garibaldi 246, 80141 Naples, Italy;
2 Clinical and experimental biology, University of Foggia, Foggia, Italy;
3 Independent Researcher, University of Bari, 70100 Bari, Italy.
*Correspondence to:
Armando Coppola,
Private practice, Studio Armando Coppola,
Corso Garibaldi 246,
80141 Naples, Italy.
e-mail: armandocoppola70@gmail.com
| Received: 01 November, 2024 Accepted: 09 December, 2024
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ISSN 2975-044X (online) ISSN 2038-4106 (print) Copyright © by BIOLIFE 2024 This publication and/or article is for individual use only and may not be further reproduced without written permission from the copyright holder. Unauthorized reproduction may result in financial and other penalties. Disclosure: All authors report no conflicts of interest relevant to this article. |
ABSTRACT
The role of anti-inflammatory drugs and polymer nano-hybrids in dentistry has attracted much interest. Nonsteroidal anti-inflammatory drugs (NSAIDs) are used in dentistry especially in pain management and gingival inflammation. These drugs have demonstrated their efficacy with acceptable and non-serious side effects. In addition, NSAIDs regulate the immune system and do not inhibit it, as occurs with steroid drugs. In dentistry, the combination of NSAIDs with polymer nano-hybrid molecules represents a new effective therapeutic treatment. Polymer nanohybrids are nanoscale materials composed of polymers and other compounds, and allow localized and sustained release of anti-inflammatory drugs, and increased retention in oral sites, with reduced toxicity. They modulate the immune system by targeting immune cells and other potentially inflammatory cells that release cytokines. Nanohybrids exert antimicrobial activity against bacterial biofilms. The ombination of NSAIDs with nanohybrid polymers improves therapeutic response in periodontal disease.
KEYWORDS: Anti-inflammatory drugs, dentistry, polymeric nano-hybrid, immune response, inflammation
