A CLINICAL INVESTIGATION OF HYALURONIC ACID FORTIFIED WITH AMINO ACIDS FOR ADDRESSING FACIAL AGING

A. Scarano^1*, A. Sbarbati², R. Amore³, E.L. Iorio⁴, G. Ferraro⁵, M. Marchetti⁶, D. Amuso² and S.R. Tari¹

¹Dean of Master course in Aesthetic Medicine, Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Italy;
²University of Palermo, Master of Techniques of Aesthetic Medicine and Wellness, Palermo, Italy;
³Department of Neurosciences, Biomedicine and Movement Sciences, Anatomy and Histology Section, University of Verona, School of Medicine, Verona, Italy;
⁴Master course in Aesthetic Medicine, Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Italy;
⁵Department of Plastic, Reconstructive and Aesthetic Surgery, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy;
⁶Ph.D School of Applied Medical-Surgical Sciences, University of Rome Tor Vergata, Rome, Italy;

*Correspondence to:
Antonio Scarano, MD, DDS
Department of Medical, Oral and Biotechnological Sciences
University of Chieti-Pescara
Via dei Vestini 31
66100 Chieti, Italy
e-mail: ascarano@unich.it

Received: 31 October 2023 Accepted: 18 December 2023

ISSN 2975-044X (online) ISSN 2038-4106 (print) Copyright © by BIOLIFE 2024 This publication and/or article is for individual use only and may not be further reproduced without written permission from the copyright holder. Unauthorized reproduction may result in financial and other penalties. Disclosure: All authors report no conflicts of interest relevant to this article.

ABSTRACT

Within the field of aesthetic medicine, various methodologies have been employed to combat skin aging, particularly in the facial region. One such approach involves the utilization of hyaluronic acid to enhance water retention and support extracellular matrix integrity. This research aims to clinically and histologically assess the impact of combining low molecular weight hyaluronic acid fragments with amino acids (HAAM) on revitalizing facial skin through intradermal microinjections. A cohort of twenty female participants, with an average age of 45 falling within the range of 35 to 64, was included in this investigation. Among them, eight were in the postmenopausal stage, while twelve were in their childbearing years. Mesotherapy was employed to administer HAAM products to the patients for 4 section. The outcomes from the current investigation revealed that applying hyaluronic acid with fragments of 20 to 38 monomers, along with amino acids through the dermal injection technique, leads to an enhancement in the visual appearance of the treated patients’ facial features. The clinical evaluation highlighted the significant influence of subcutaneous HAAM infiltration on both the dermis, improve pH levels, sebum production, skin hydration and enhance the overall clinical presentation of the facial region.

KEYWORDS: skin imperfections, cutaneous biostimulation, hyaluronic acid fragments, aesthetic enhancement