INCIDENTAL DIAGNOSIS OF MIKULICZ DISEASE: A CASE REPORT

M. Bonetti¹, M. Frigerio¹, G. Sabetta², R. Degliuomini² and S. Bonetti³

¹Department of Neuroradiology, Clinical Institute, Città di Brescia, Brescia, Italy;
²Vita-Salute San Raffaele University, Milan, Italy;
³Gynaecological Department, Clinical Institute, Città di Brescia, Brescia, Italy

*Correspondence to:
Matteo Bonetti, MD
Neuroradiology Department,
Clinical Institute, Città di Brescia,
Via Gualla 15,
25128 Brescia, Italy
e-mail: dottorbonetti@gmail.com

Received:  04 May  2023 Accepted: 05 June 2023

2038-4106(2023) Copyright © by BIOLIFE This publication and/or article is for individual use only and may not be further reproduced without written permission from the copyright holder. Unauthorized reproduction may result in financial and other penalties. Disclosure: all authors report no conflicts of interest relevant to this article.

ABSTRACT

Mikulicz Disease (MD) is a chronic autoimmune condition considered part of the IgG4-related disease. Its aetiology is unknown. Furthermore, like all autoimmune diseases, it predominantly affects women. MD is characterized by the abnormal enlargement of salivary and lacrimal glands. In addition, it is characterized by significant plasma cell infiltration in lacrimal and salivary glands and high IgG4 serum levels. Therefore, ultrasound (US) examination, Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) may be beneficial in the diagnosis of MD. In this case report, we describe an incidental diagnosis of MD after orbit magnetic resonance in a 46 years old female patient.

KEYWORDS: Mikulicz syndrome, Mikulicz’s disease, dacryosialoadenopathy, immunoglobulin G4, Mikulicz-Radecki syndrome